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musculoskeletal

American  
[muhs-kyuh-loh-skel-i-tl] / ˈmʌs kjə loʊˈskɛl ɪ tl /

adjective

  1. concerning, involving, or made up of both the muscles and the bones.

    the musculoskeletal system.


musculoskeletal British  
/ ˌmʌskjʊləʊˈskɛlɪtəl /

adjective

  1. of or relating to the skeleton and musculature taken together

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of musculoskeletal

First recorded in 1940–45; musculo- + skeletal

Vocabulary lists containing musculoskeletal

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Lilly had paid Boston-based Centrexion Therapeutics $47.5 million upfront for the exclusive worldwide rights to the drug, which was being developed for chronic inflammatory, neuropathic, and musculoskeletal pain.

From Barron's Jun. 16, 2026

In addition to their limited effectiveness, opioids were linked to a higher risk of side effects in several situations, including acute musculoskeletal pain, traumatic limb injuries, and some forms of post surgical pain.

From Science Daily Jun. 9, 2026

Research suggests that more than half of golfers will experience a musculoskeletal injury at some point in their playing careers.

From The Wall Street Journal Apr. 6, 2026

Collagen is the most abundant protein in the body, and forms the scaffolding that helps maintain the structural integrity of our skin and musculoskeletal system.

From BBC Sep. 27, 2025

She had amplified musculoskeletal pain syndrome, or AMPS—and he had a treatment that could cure her.

From Slate Sep. 15, 2025

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