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naloxone

American  
[nuh-lok-sohn, nal-uhk-sohn] / nəˈlɒk soʊn, ˈnæl əkˌsoʊn /

noun

Pharmacology.
  1. an opioid antagonist, C 19 H 21 NO 4 , used to reverse the acute respiratory depression that occurs with opioid overdose.


naloxone British  
/ nəˈlɒksəʊn /

noun

  1. a chemical substance that counteracts the effects of opiates by binding to opiate receptors on cells

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of naloxone

First recorded in 1960–65; by shortening and rearrangement of dihydroxy-, morphinan-, and -one, components of its chemical name

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Telemedicine and mobile clinics have made access to treatment more accessible for some communities, and policy changes in recent years have increased access to the overdose-reversing drug naloxone.

From The Wall Street Journal ● May 13, 2026

She is a nurse with more than 30 years' experience and can prescribe treatments and hand out naloxone, which she describes as "like a duty of care or a moral issue".

From BBC ● Feb. 12, 2026

It was thanks to Bigg’s efforts that naloxone became accepted nationwide.

From Salon ● May 24, 2025

But in the face of numerous news reports about the proposed cuts, Kennedy has not offered full-throated, public support for the naloxone program.

From Los Angeles Times ● May 4, 2025

Most often administered as a nasal spray, naloxone finds and replaces opioid receptors, binding stronger than the opioid and effectively blocking it.

From Los Angeles Times ● Jun. 6, 2024

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