[ of-ee-yoo-kuh s, oh-fee- ]
/ ˌɒf iˈyu kəs, ˌoʊ fi- /

noun, genitive Oph·i·u·chi [of-ee-yoo-kahy, oh-fee-] /ˌɒf iˈyu kaɪ, ˌoʊ fi-/. Astronomy.

the Serpent Bearer, a constellation on the celestial equator between Libra and Aquila.
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British Dictionary definitions for ophiuchus

/ (ɒˈfjuːkəs) /

noun Latin genitive Ophiuchi (ɒˈfjuːkaɪ)

a large constellation lying on the celestial equator between Hercules and Scorpius and containing the dark nebula, Ophiuchus Nebula

Word Origin for Ophiuchus

C17: via Latin from Greek Ophioukhos, from ophis snake + ekhein to hold
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012