- Cell Biology. one of the large multinuclear cells in growing bone concerned with the absorption of osseous tissue, as in the formation of canals.
- Surgery. an instrument for effecting osteoclasis.
Origin of osteoclast
1870–75; osteo- + -clast < Greek klastós broken
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
- a surgical instrument for fracturing bone
- a large multinuclear cell formed in bone marrow that is associated with the normal absorption of bone
- A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.osteophage
- An instrument used in surgical osteoclasis.
- A specialized bone cell that absorbs bone, allowing for the deposition of new bone and maintenance of bone strength. Osteoclasts secrete enyzmes that dissolve the matrix of old bone tissue and acids that dissolve bone salts, which contain calcium and phosphorus. Except in growing bone, the rate of bone deposition and bone absorption equal each other so that bone mass remains constant. A mass of osteoclasts absorbs bone from the outer surfaces inward for about three weeks. The osteoclasts are then converted into osteoblasts that form new bone to fill in the cavities. See also osteoblast.
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