paroxetine

[puh-rok-si-teen, par-ok-]

noun

Pharmacology.

1. a drug, C 19 H 20 FNO 3 HCl, of the SSRI class, that acts by prolonging the action of serotonin in the brain, used in the treatment of depression and anxiety disorders.

paroxetine

/ pæˈrɒksətiːn /

noun

1. an antidepressant drug that acts by preventing the re-uptake after release of serotonin in the brain, thereby prolonging its action: used for treating depression, obsessive-compulsive disorders, and panic disorder. Formula: C 19 H 20 FNO 3

Word History and Origins

Origin of paroxetine¹

First recorded in 1975–80; of uncertain origin, but perhaps based on piperidine ( def. ) with the infix ox- ( def. )

Example Sentences

Dr Toby Pillinger says: John should avoid drugs such as venlafaxine, amitriptyline or nortriptyline which raise blood pressure, and would be better suited to citalopram, escitalopram and paroxetine.

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Dr Toby Pillinger says: For Jane, some antidepressants are linked to higher cholesterol, including venlafaxine, duloxetine and paroxetine, so she might steer clear of those.

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Overall, the most prescribed class of antidepressants - SSRIs such as paroxetine, citalopram, escitalopram and sertraline - tended to have fewer physical side effects.

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These kinds of symptoms were more common after discontinuing treatment with the drugs imipramine, paroxetine, venlafaxine, and desvenlafaxine.

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The antidepressants sertraline and paroxetine, both greenlit by FDA in 2000, generally have a small effect and work in less than two-thirds of patients, Rothbaum notes.

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