peptidase

[pep-ti-deys, -deyz]

noun

Biochemistry.

1. any of the class of enzymes that catalyze the hydrolysis of peptides or peptones to amino acids.

peptidase

/ -ˌdeɪz, ˈpɛptɪˌdeɪs /

noun

1. any of a group of proteolytic enzymes that hydrolyse peptides to amino acids

Word History and Origins

Origin of peptidase¹

First recorded in 1915–20; peptide + -ase

Example Sentences

And perhaps most importantly, the modifications resulted in a molecule that bound and inhibited signal peptidase in a completely novel way, overcoming known arylomycin-resistance mutations.

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The frequently mutated apoptosis gene CASP8 displayed clustered missense and other inactivating mutations in the first death effector, intron and caspase peptidase domains.

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We generated over a thousand new molecules until we found ones that could penetrate the outer membrane and engage the signal peptidase with exquisite affinity.

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Because signal peptidase is essential for bacterial survival, it’s an obvious antibiotic target.

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Our discovery efforts started with arylomycins, a class of molecules that target a protein called signal peptidase, which lies just beneath the outer membrane in gram-negative bacteria.

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