peptide bond

noun

Biochemistry.

1. a covalent bond formed by joining the carboxyl group of one amino acid to the amino group of another, with the removal of a molecule of water.

peptide bond

noun

1. biochem a chemical amide linkage, –NH–CO–, formed by the condensation of the amino group of one amino acid with the carboxyl group of another

peptide bond

1. The chemical bond formed between amino acids, constituting the primary linkage in all protein structures. In a peptide bond, the carboxyl group (COOH) of one amino acid bonds with the amino group (NH ₂) of another, forming the sequence CONH and releasing water (H ₂ O).

Word History and Origins

Origin of peptide bond¹

First recorded in 1930–35

Example Sentences

The molecule, methyl isocyanate, has a structure that is chemically similar to a peptide bond, which is what holds amino acids together in proteins.

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Moreover, he was privy to a discussion in which the fundamental blunder about the shape of the peptide bond was made.

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When a peptide bond forms, a water molecule is released.

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Pauling had cracked the a-helix by ruthlessly following up his knowledge that the peptide bond was flat.

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When a water molecule encounters the weakened peptide bond, it likely now has enough energy to break it, recombining with the broken ends to reform the loose amino acid.

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