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polynucleotide

American  
[pol-ee-noo-klee-uh-tahyd, -nyoo-] / ˌpɒl iˈnu kli əˌtaɪd, -ˈnju- /

noun

Biochemistry.
  1. a sequence of nucleotides, as in DNA or RNA, bound into a chain.


polynucleotide British  
/ ˌpɒlɪˈnjuːklɪəˌtaɪd /

noun

  1. biochem a molecular chain of nucleotides chemically bonded by a series of ester linkages between the phosphoryl group of one nucleotide and the hydroxyl group of the sugar in the adjacent nucleotide. Nucleic acids consist of long chains of polynucleotides

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of polynucleotide

First recorded in 1910–15; poly- + nucleotide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

A single session of polynucleotide injections can cost anywhere from £200 to £500 - and it's recommended you have three of these over several weeks.

From BBC Nov. 21, 2025

A polynucleotide may have thousands of such phosphodiester linkages.

From Textbooks Jun. 9, 2022

When a polynucleotide is formed, the 5′ phosphate of the incoming nucleotide attaches to the 3′ hydroxyl group at the end of the growing chain.

From Textbooks Jun. 9, 2022

The nucleotides combine with each other to form a polynucleotide, DNA or RNA.

From Textbooks Jun. 9, 2022

Division of the RNA component into a large number of subunits would produce polynucleotide chains too small to carry the genetic information that Francis and I believed must reside in the viral RNA.

From "Double Helix" by James D. Watson

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