- the first stage of syphilis, characterized by the formation of a chancre at the site of infection.
Origin of primary syphilis
First recorded in 1900–05
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
- The first stage of syphilis, marked by formation of a painless chancre at the point of infection and by hardening and swelling of adjacent lymph nodes.