pseudotuberculosis

[soo-doh-too-bur-kyuh-loh-sis, -tyoo-]

noun

Pathology.

1. an acute, sometimes fatal disease of rodents, birds, and other animals, including humans, caused by the bacterium Yersinia (Pasteurella) pseudotuberculosis, and characterized by the formation of nodules resembling those that result from tuberculosis.

2. any disease resembling tuberculosis but caused by an organism other than Mycobacterium tuberculosis.

Word History and Origins

Origin of pseudotuberculosis¹

First recorded in 1895–1900; pseudo- + tuberculosis; pseudotuberculosis def. 1 after the species name of the bacterium causing the disease

Example Sentences

Zhou et al. took an unbiased approach and screened a collection of Y. pseudotuberculosis genetic mutants to identify bacterial genes that are linked to NF-κB activation in response to infection.

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The authors report slight differences in the way in which ADP-Hep and ADP-heptose 7-P bind to ALPK1, and use these differences to demonstrate why ADP-Hep and not HBP or ADP-heptose 7-P is the relevant ligand for ALPK1-mediated NF-κB activation, at least in Y. pseudotuberculosis infection.

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In Y. pseudotuberculosis, this process requires the T3SS, although it is unclear whether ADP-Hep is actively transported or accidentally leaks through the T3SS, or whether it enters by the pores that the T3SS generates in the host-cell membrane.

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Although Zhou et al. show that ADP-Hep is the relevant immune-triggering ligand for Y. pseudotuberculosis infections, it remains to be seen whether HBP is converted into ADP-heptose 7-P during other bacterial infections.

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Zhou and colleagues studied human cells grown in vitro to try to identify pathways that activate NF-κB in response to infection by the bacterium Yersinia pseudotuberculosis.

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