Southern blot

American  

noun

Biology, Medicine/Medical.

1. a procedure for identifying and measuring the amount of a specific DNA sequence or gene in a mixed extract, as in testing for a mutation or a virus: DNA strands from the person or organism under study are cut with restriction enzymes, separated by gel electrophoresis, transferred to special filter paper, and hybridized with a labeled DNA probe.

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Etymology

Origin of Southern blot

After Edwin M. Southern, originator of the technique

Compare meaning

How does southern-blot compare to similar and commonly confused words? Explore the most common comparisons:

• Southern blot vs. Western blot
• Northern blot vs. Southern blot

Example Sentences

Application of this method to DNA is called a Southern blot, named for the inventor of the technology.

From Textbooks • Jun. 9, 2022

Is knowing about somatic hypermutation in a Southern blot really making me a better physician and health policy researcher and advocate?

From Scientific American • Mar. 12, 2020

He soon found that some Step 1 questions were testing analysis of Southern blot, a molecular biology testing mechanism, or the biochemical pathways that influence the position of a cell within an organ.

From Scientific American • Mar. 12, 2020