Dictionary.com
Thesaurus.com

spermidine

American  
[spur-mi-deen, -din] / ˈspɜr mɪˌdin, -dɪn /

noun

Biochemistry.
  1. a biogenic polyamine, H 2 N(CH2 ) 4 NH(CH2 ) 3 NH 2 , formed from putrescine, occurring widely in nature and first identified in semen.


Etymology

Origin of spermidine

First recorded in 1925–30; sperm- + -idine

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Lubiprostone increased the production of spermidine, a naturally occurring compound tied to healthier mitochondrial activity.

From Science Daily • May 8, 2026

They first reduced polyamine levels using a drug, then restored them by adding spermidine.

From Science Daily • Mar. 2, 2026

They determined that lubiprostone boosts the production of spermidine, a compound that enhances mitochondrial activity by encouraging the growth of beneficial gut bacteria.

From Science Daily • Dec. 3, 2025

Guanosine monophosphate and inosine monophosphate are known to signal to G-protein-coupled adenosine receptors9, and spermidine can participate in a broad range of activities.

From Nature • Mar. 17, 2020

Medina and colleagues traced the conversion of arginine to spermidine by this pathway, and found that cells induced to undergo apoptosis increased their synthesis of spermidine and its precursor, the molecule putrescine, before dying.

From Nature • Mar. 17, 2020

Vocabulary.com logo
by dictionary.com

Look it up. Learn it forever.

Remember "spermidine" for good with VocabTrainer. Expand your vocabulary effortlessly with personalized learning tools that adapt to your goals.

Take me to Vocabulary.com