sphingosine

American  

[sfing-guh-seen, -sin] / ˈsfɪŋ gəˌsin, -sɪn /

noun

Biochemistry.

1. a basic unsaturated amino alcohol, C 1 8 H 3 3 (OH) 2 NH 2 , produced by the hydrolysis of sphingomyelin or gangliosides.

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sphingosine British  

/ -ˌsiːn, ˈsfɪŋɡəsɪn /

noun

1. biochem a long-chain compound occurring in sphingomyelins and cerebrosides, and from which it can be released by hydrolysis. Formula: CH 3 (CH 2 ) 12 CH:CHCH(OH)CH(NH 2 )CH 2 OH

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Etymology

Origin of sphingosine

1881; earlier sphingosin, equivalent to sphingo-, combining form representing Greek sphínx sphinx + intrusive -s- + -in ²; so called in allusion to the enigmas it posed for its discoverer

Example Sentences

The study also opens new avenues on how the B12-TCN2-CD320 pathway is regulated by sphingolipids, specifically sphingosine, a naturally occurring and endogenous structural analog of fingolimod, toward improving future MS therapies, Chun said.

From Science Daily

Previous work12 has shown that a different lipid mediator that acts on endothelial cells, the molecule sphingosine 1-phosphate, induces the formation of adherens junctions and promotes the development of blood vessels.

From Nature

Ceramides, which are composed of a sphingosine and a fatty acid, oppose many of the effects of adiponectin.

From Science Magazine

Sphingosine, the breakdown product of ceramide, exerted adiponectin-like effects and inhibited apoptosis, which suggests that ceramidase activity, not AMPK, is central to AdipoR signaling.

From Science Magazine