spironolactone

American  

[spahy-ruh-noh-lak-tohn, spahy-roh-, -ron-uh-] / ˌspaɪ rə noʊˈlæk toʊn, spaɪˌroʊ-, -ˌrɒn ə- /

noun

Pharmacology.

1. a steroid, C 2 4 H 3 2 O 4 S, used in combination with other drugs as a diuretic and antihypertensive.

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spironolactone British  

/ ˌspaɪrənəʊˈlæktəʊn /

noun

1. a diuretic that increases water loss from the kidneys and is much used to treat oedema in heart and kidney failure

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Etymology

Origin of spironolactone

1955–60; alteration of spirolactone; see spiro- ², lactone

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Example Sentences

See Examples For:

spironolactone

Some dermatologists recommend birth control, which can help stabilize hormones, or treatments such as spironolactone.

From Los Angeles Times ● Oct. 13, 2026

Cooper asked USA Powerlifting for a “therapeutic-use exemption” to take spironolactone, a medicine prescribed to treat her gender dysphoria, “but JayCee was denied because she’s transgender,” Braverman said.

From Seattle Times ● Mar. 18, 2024

Cooper, who was taking the testosterone-reducing drug spironolactone, continued to compete in contests run by Open Powerlifting, capturing first place in five championship events in 2019.

From Washington Times ● Mar. 2, 2023

The Endocrine Society's guideline notes that eplerenone has fewer side effects but is less potent than spironolactone and must be taken more often.

From Salon ● Feb. 26, 2022

Gearhart had prescriptions for metformin, spironolactone and a thyroid medication from Randolph Whipps, the founding physician of LifeMed Institute in Maryland, which bills itself as the largest concierge wellness facility on the East Coast.

From Washington Post

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