SRY gene

noun

Genetics.

1. a sex-determining gene on the Y chromosome in mammals that determines maleness and is essential for development of the testes.

Word History and Origins

Origin of SRY gene¹

First recorded in 1990–95; abbreviation of s(ex-determining) r(egion) Y

Example Sentences

If a human embryo has XY chromosomes the SRY gene leads to the formation of testes, which then produce hormones including testosterone that lead to male development - and can increase muscle mass and strength.

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The test for the SRY gene - which is part of the Y chromosome and causes male characteristics to develop - can be conducted via a cheek swab or blood test.

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A cheek swab test would be used to look for the SRY gene, while a dried blood spot test could also be used to determine an athlete's testosterone levels - in addition to the presence of the SRY gene.

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The test for the SRY gene, which is "almost always on the male Y chromosome" and "is used as a highly accurate proxy for biological sex", would need to be taken just once by an athlete during their career.

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This decision results from the coordinated activity of a set of genes, such as the Sry gene on the Y chromosome which has a short window of time to drive testes development.

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