Tay-Sachs disease

[ tey-saks ]
/ ˈteɪˈsæks /

noun Pathology.

a rare fatal hereditary disease, occurring chiefly in infants and children, especially of eastern European Jewish origin, characterized by a red spot on the retina, gradual blindness, and paralysis.



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Origin of Tay-Sachs disease

1920–25; named after W. Tay (1843–1927), English physician, and B. Sachs (1858–1944), American neurologist

Words nearby Tay-Sachs disease

Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020

British Dictionary definitions for Tay-Sachs disease

Tay-Sachs disease
/ (ˌteɪˈsæks) /


an inherited disorder, caused by a faulty recessive gene, in which lipids accumulate in the brain, leading to mental retardation and blindness. It occurs mostly in Ashkenazi Jews

Word Origin for Tay-Sachs disease

C20: named after W. Tay (1843–1927), British physician, and B. Sachs (1858–1944), US neurologist
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medical definitions for Tay-Sachs disease

Tay-Sachs disease
[ tāsăks′ ]


A liposomal storage disease that is the infantile type of cerebral sphingolipidosis.GM2 gangliosidosis
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

Scientific definitions for Tay-Sachs disease

Tay-Sachs disease
[ tāsăks′ ]

A genetic disease in which the products of fat metabolism accumulate in the nervous system, causing retardation, paralysis, and death by preschool age. Individuals of eastern European Jewish descent have a higher risk of inheriting Tay-Sachs disease. The disease is named after its describers, British ophthalmologist Warren Tay (1843-1927) and American neurologist Bernard Sachs (1858-1944).
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.