untune

[uhn-toon, -tyoon]

verb (used with object), un·tuned, un·tun·ing.

to render or cause to become out of tune: Changes in weather can untune a violin.
to discompose; upset, as the mind or emotions.

Origin of untune

First recorded in 1590–1600; un-² + tune

To my ear the untune is agony; to my music, a discord in my day is death to what would have been written that day.
A Woman's Will
Anne Warner