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virulent

American  
[vir-yuh-luhnt, vir-uh-] / ˈvɪr jə lənt, ˈvɪr ə- /

adjective

  1. actively poisonous; intensely noxious.

    a virulent insect bite.

    Synonyms:
    venomous
    Antonyms:
    harmless
  2. Medicine/Medical. highly infective; malignant or deadly.

  3. Bacteriology. causing clinical symptoms.

  4. violently or spitefully hostile.

  5. intensely bitter, spiteful, or malicious.

    a virulent attack.

    Synonyms:
    acerbic, vicious

virulent British  
/ ˈvɪrʊlənt /

adjective

    1. (of a microorganism) extremely infective

    2. (of a disease) having a rapid course and violent effect

  1. extremely poisonous, injurious, etc

  2. extremely bitter, hostile, etc

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of virulent

1350–1400; Middle English verulent < Latin vīrulentus, equivalent to vīr ( us ) poison ( see virus) + -ulentus -ulent

Explanation

A virulent disease is one that's infectious, spreading, and making lots of people sick, while a virulent rant is just a verbal attack, causing sickness of the emotional kind. Either way, something virulent puts a strain on the people who get it. Two meanings come out of the roots for virulent: "poisonous" and "spiteful." The virus-carrying meaning of virulent often gets combined with strain, such as in a "virulent strain of the flu." Those who aren’t carrying disease but are still considered virulent most likely lash out at others with a biting tone. Unleashing acid-tongued words on someone would be considered a virulent attack.

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Vocabulary lists containing virulent

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

“When a strain is less virulent, as in the case of the Bundibugyo strain, infected people feel sick, but not sick enough to be bedridden or abandon their daily routines.”

From The Wall Street Journal Aug. 6, 2026

But his decision to endorse a major offshore oil exploration project off the coast of the Amazon has garnered virulent criticism from activists.

From Barron's Jul. 21, 2026

The Fontainebleau forest blaze, described by officials as "virulent" and of "exceptional scale", partially closed the country's main north-south highway, disrupting traffic during the first major weekend getaway of the summer.

From BBC Jul. 13, 2026

"The bumpier, irregular surface of the virulent strains exposes parts of the virus that are normally hidden, allowing certain antibodies to attach more easily," Dr. Bibby said.

From Science Daily Nov. 27, 2025

Myth number three: MDR was less virulent and contagious than regular TB.

From "Mountains Beyond Mountains" by Tracy Kidder and Michael French

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