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amitriptyline

American  
[am-i-trip-tuh-leen, -lahyn, -lin] / ˌæm ɪˈtrɪp təˌlin, -ˌlaɪn, -lɪn /

noun

Pharmacology.
  1. a white crystalline powder, C 20 H 23 N, used to treat depression and enuresis.


amitriptyline British  
/ ˌæmɪˈtrɪptɪˌliːn, -lɪn /

noun

  1. a tricyclic antidepressant drug. Formula: C 20 H 23 N

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of amitriptyline

Perhaps ami(no)- + trypt(ophan) + (meth)yl + -ine 2

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Dr Toby Pillinger says: Sarah should have an antidepressant that avoids weight gain, such as agomelatine, sertraline or venlafaxine rather than amitriptyline or mirtazapine which are more likely to increase weight.

From BBC Oct. 21, 2025

The results, published today in The Lancet, showed that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.

From Science Daily Oct. 16, 2023

The first three “might be considered first choice” by doctors, they write, although the two most effective drugs – amitriptyline and venlafaxine – might still be first choice for severe depression.

From The Guardian Feb. 21, 2018

Others have used low doses of tricyclic antidepressants, such as amitriptyline to treat chronic pain.

From US News May 24, 2016

I take amitriptyline at night to help me sleep.

From Seattle Times Aug. 1, 2012

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