[an-ti-his-tuh-meen, -min]

noun Physiology, Pharmacology.

any of certain compounds or medicines that neutralize or inhibit the effect of histamine in the body, used chiefly in the treatment of allergic disorders and colds.

Origin of antihistamine

First recorded in 1930–35; anti- + histamine Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Examples from the Web for antihistamine

Contemporary Examples of antihistamine

British Dictionary definitions for antihistamine



any drug that neutralizes the effects of histamine, used esp in the treatment of allergies
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Word Origin and History for antihistamine

1933, from anti- + histamine.

Online Etymology Dictionary, © 2010 Douglas Harper

antihistamine in Medicine


[ăn′tē-hĭstə-mēn′, -mĭn]


Any of several drugs used to counteract the physiological effects of histamine.
Related formsan′ti•hista•mine′ adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

antihistamine in Science



Any of various drugs that relieve cold or allergy symptoms by blocking the action of histamine.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.