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antisense RNA

/ ˈæntɪsɛns /

noun

  1. molecules transcribed, not from DNA in the usual way, but from DNA strands complementary to those that produce normal messenger RNA. Antisense RNA occurs in nature and is inhibitory on gene action. It can be produced synthetically and offers such therapeutic possibilities as turning off viral genes

“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012


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To interrupt that process, antisense RNA therapies inject cells with RNA strands that bind to specific mRNA snippets, effectively blocking them from being read by ribosomes.

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To date, only two antisense RNA therapies have been approved in the United States, despite decades of effort and dozens of clinical trials.

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The general approach to RNA therapy, called antisense RNA, aims to disrupt the production of proteins related to diseases like cancer and HIV.

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The trouble is that traditional antisense RNA drugs usually don’t work.

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By changing the RNA code on the SNA particles, it could open a new pathway for antisense RNA therapies.

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