apolipoprotein

[ap-uh-lip-uh-proh-teen, -tee-in, -lahy-puh-]

noun

Biochemistry.

1. the lipid-free protein portion of a lipoprotein.

apolipoprotein

/ -ˌlaɪ-, ˌæpəˌlɪpəʊˈprəʊtiːn /

noun

1. any of a group of glycoproteins that form part of the structure of lipoproteins, some of which have been associated with Alzheimer's disease

apolipoprotein

1. Any of various proteins that combine with a lipid to form a lipoprotein, such as high density lipoprotein (HDL) and low density lipoprotein (LDL). Apolipoproteins are important in the transport of cholesterol in the body and the regulation of the level of cholesterol in cells and blood.

Word History and Origins

Origin of apolipoprotein¹

apo- + lipoprotein

Example Sentences

In addition, the study provides evidence that deficiency of apolipoprotein E, a protein involved in lipid metabolism results in a signature of accelerated endothelial aging.

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It picked up the well-known association between Alzheimer's and high cholesterol, through a variant form of the apolipoprotein E gene, APOE4.

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Advanced age and carrying the apolipoprotein ε4 risk gene are already known risk factors.

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It encodes the protein apolipoprotein E, which is involved in fat and cholesterol metabolism.

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In another experiment, we used the tau mouse model, which also expressed human APOE4, to test whether reducing levels of the apolipoprotein variant would protect against neurodegeneration.

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