asparaginase

American  

[uh-spar-uh-juh-neys, -neyz] / əˈspær ə dʒəˌneɪs, -ˌneɪz /

noun

Biochemistry, Pharmacology.

1. an enzyme that catalyzes the conversion of asparagine to aspartic acid and ammonia, used in the treatment of acute lymphocytic leukemia.

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Etymology

Origin of asparaginase

First recorded in 1960–65; asparagine + -ase

Example Sentences

"Ideally, we aim for venetoclax to potentiate the anti-leukemia properties of asparaginase while keeping its toxicity levels in check. These concepts warrant further investigation in future clinical trials."

From Science Daily

The global supply of high-quality medicines is also of key concern, said Lam, pointing to issues with asparaginase, an essential medicine for the most common childhood cancer, acute lymphoblastic leukaemia, as an example.

From The Guardian

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.

From Nature

“People who have the enzyme asparaginase, it breaks down asparagine, which is what is in asparagus, and their urine doesn’t smell,” O’Leary says.

From US News

But her medical records show she was taking methotrexate, vincristine, doxorubicin, asparaginase, prednisone, cyclophosphamide and cytarabine, and had 12 rounds of radiation to her developing brain.

From Nature