Dictionary.com
Thesaurus.com

autoimmune

American  
[aw-toh-i-myoon] / ˌɔ toʊ ɪˈmyun /

adjective

Immunology.
  1. of or relating to the immune response of an organism against any of its own tissues, cells, or cell components.


autoimmune British  
/ ˌɔːtəʊɪˈmjuːn /

adjective

  1. (of a disease) caused by the action of antibodies produced against substances normally present in the body

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • autoimmunity noun

Etymology

Origin of autoimmune

First recorded in 1950–55; auto- 1 + immune

Explanation

When a condition or illness is described as autoimmune, it means the body's immune system is attacking the body's own cells or tissues. Lupus is one example of an autoimmune disease. Your immune system sends out antibodies to attack bacteria and viruses that shouldn't be in your body. When this system mistakenly attacks substances that are meant to be in your body, it can cause all kinds of problems — this is an autoimmune disorder. Autoimmune is a medical term that's been around since the 1950s, from auto-, "self," and immune, "exempt from a disease."

Keep Reading on Vocabulary.com

Vocabulary lists containing autoimmune

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Type 1 diabetes is an autoimmune disease that affects more than 130,000 Australians.

From Science Daily • Apr. 15, 2026

Key to J&J’s future is Tremfya, an IL-23 inhibitor used to treat several autoimmune conditions, such as plaque psoriasis.

From MarketWatch • Apr. 14, 2026

Notably, six of those 19 deals came from just two companies: Gilead Sciences and Eli Lilly, spanning cancer, autoimmune diseases and sleep disorders.

From The Wall Street Journal • Apr. 13, 2026

Gilead Sciences will acquire Ouro Medicines for $2.18 billion to bolster its autoimmune drug portfolio.

From Barron's • Mar. 24, 2026

“I don’t know. It just happens to some people. That’s the way autoimmune diseases are.”

From "How to Disappear Completely" by Ali Standish