Dictionary.com
Thesaurus.com
Synonyms

Big C

American  
Or big C

noun

Slang.
  1. cancer.


Etymology

Origin of Big C

First recorded in 1970–75

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

“Sometimes we talk about little-c Canadian or big-C Canadian,” Cohan says.

From The Wall Street Journal • Jan. 22, 2026

“We are looking for people who have demonstrated what I would call big-C creativity,” Cecilia Conrad, a managing director of the foundation and the head of the fellows program, said.

From New York Times • Sep. 25, 2019

There are small-C conspiracy theories and big-C conspiracy theories.

From Salon • May 23, 2017

This is usually the moment when a frequent advocate for big-C cinema makes an impassioned case for the technical and aesthetic superiority of the theatrical experience.

From Washington Post • Oct. 15, 2015

Vocabulary.com logo
by dictionary.com

Look it up. Learn it forever.

Remember "Big C" for good with VocabTrainer. Expand your vocabulary effortlessly with personalized learning tools that adapt to your goals.

Take me to Vocabulary.com