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cytokine storm

American  
[sahy-tuh-kahyn stawrm] / ˈsaɪ təˌkaɪn ˈstɔrm /

noun

  1. an overreaction of the immune system, in which an excess of cytokines triggers an onslaught of white blood cells that swarm an infected area of the body, resulting in inflammation, possible tissue damage, and in extreme cases, organ failure.

    A cytokine storm in the lungs of a COVID-19 patient can draw hungry white blood cells into the spaces between air sacs, blocking oxygen from reaching the blood, which can prove fatal.


Etymology

Origin of cytokine storm

First recorded in 1990–95

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

But in some cases of severe infection, the immune system can overcorrect and send out an excess amount of these proteins, a serious and potentially fatal reaction called a cytokine storm.

From Los Angeles Times Jun. 15, 2026

People with traumatic injuries and those taking some cancer immunotherapies can also experience a cytokine storm.

From Science Daily Jan. 17, 2024

An elevated release of proteins known as cytokines can result in a cytokine storm, sparking inflammation and damaging key organs such as the heart.

From Washington Times Jan. 27, 2023

Other scientists have suggested that children’s developing immune systems have lower levels of the proteins that can cause the potentially deadly immune response known as a cytokine storm.

From Washington Post Sep. 26, 2022

"Whether or not antihistamines are the answer, it could prove useful in understanding its role in tamping down the cytokine storm."

From Salon Feb. 22, 2022

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