degeneration
Americannoun
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the process of degenerating.
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the condition or state of being degenerate.
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Pathology.
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a process by which a tissue deteriorates, loses functional activity, and may become converted into or replaced by other kinds of tissue.
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the condition produced by such a process.
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noun
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the process of degenerating
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the state of being degenerate
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biology the loss of specialization, function, or structure by organisms and their parts, as in the development of vestigial organs
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impairment or loss of the function and structure of cells or tissues, as by disease or injury, often leading to death (necrosis) of the involved part
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the resulting condition
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electronics negative feedback of a signal
Other Word Forms
Etymology
Origin of degeneration
First recorded in 1475–85, degeneration is from the Late Latin word dēgenerātiōn- (stem of dēgenerātiō ). See de-, generation
Explanation
Degeneration is a process of decline. Anything that’s getting worse is going through degeneration. A grand old mansion that’s now abandoned and covered with weeds is in a state of degeneration. When something degenerates, it gets worse in some way, like a house that’s slowly sinking in the mud. This process of decline is called degeneration. The word is from the Latin word degenerare which means "to be inferior to one's ancestors.” Ouch. Now degeneration refers to anything in a state of decline, such as a friendship that was strong and now barely exists.
Vocabulary lists containing degeneration
This Week in Words: April 6–12, 2019
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Tears of a Tiger
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All Quiet on the Western Front
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Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
In Alzheimer's disease, researchers have long observed that mitochondrial problems appear alongside neuronal degeneration, often before cells die.
From Science Daily • May 16, 2026
The observed continuum came from a degeneration of states caused by competing ferromagnetic and antiferromagnetic interactions, not from quantum behavior.
From Science Daily • Apr. 22, 2026
That doctor looked at the back of Kekoa’s eyes and diagnosed him with myopic degeneration, a dramatic form of nearsightedness.
From Los Angeles Times • Apr. 4, 2026
Apellis has two approved drugs: Empaveli, which is approved to treat two rare kidney diseases, and Syforvre, which is used by patients with geographic atrophy, an advanced form of dry age-related macular degeneration.
From MarketWatch • Mar. 31, 2026
It’s a fascinating study of the degeneration of the human spirit.
From "Tears of a Tiger" by Sharon M. Draper
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
