Dictionary.com
Thesaurus.com
Synonyms

degeneration

American  
[dih-jen-uh-rey-shuhn] / dɪˌdʒɛn əˈreɪ ʃən /

noun

  1. the process of degenerating.

  2. the condition or state of being degenerate.

  3. Pathology.

    1. a process by which a tissue deteriorates, loses functional activity, and may become converted into or replaced by other kinds of tissue.

    2. the condition produced by such a process.


degeneration British  
/ dɪˌdʒɛnəˈreɪʃən /

noun

  1. the process of degenerating

  2. the state of being degenerate

  3. biology the loss of specialization, function, or structure by organisms and their parts, as in the development of vestigial organs

    1. impairment or loss of the function and structure of cells or tissues, as by disease or injury, often leading to death (necrosis) of the involved part

    2. the resulting condition

  4. electronics negative feedback of a signal

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of degeneration

First recorded in 1475–85, degeneration is from the Late Latin word dēgenerātiōn- (stem of dēgenerātiō ). See de-, generation

Explanation

Degeneration is a process of decline. Anything that’s getting worse is going through degeneration. A grand old mansion that’s now abandoned and covered with weeds is in a state of degeneration. When something degenerates, it gets worse in some way, like a house that’s slowly sinking in the mud. This process of decline is called degeneration. The word is from the Latin word degenerare which means "to be inferior to one's ancestors.” Ouch. Now degeneration refers to anything in a state of decline, such as a friendship that was strong and now barely exists.

Keep Reading on Vocabulary.com

Vocabulary lists containing degeneration

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The findings could also help guide research into eye diseases including macular degeneration and glaucoma.

From Science Daily Aug. 23, 2026

Solicitor-advocate Stephen Biggam, defending, said MacPherson was deaf and suffering from the eye condition macular degeneration.

From BBC Aug. 20, 2026

A diagnosis of CTE requires evidence of degeneration of brain tissue that can only be seen during an autopsy.

From Los Angeles Times Jul. 30, 2026

At the same time, researchers noted that GLP-1 drugs may benefit some eye conditions, including age related macular degeneration and uveitis.

From Science Daily May 23, 2026

It’s a fascinating study of the degeneration of the human spirit.

From "Tears of a Tiger" by Sharon M. Draper

Vocabulary.com logo
by dictionary.com

Dictionary.com's Learning Companion

Go beyond just looking up words.
Remember them forever with VocabTrainer.

Start training