1. Also called endoblast. Embryology. the innermost cell layer of the embryo in its gastrula stage.
  2. Anatomy. the innermost body tissue that derives from this layer, as the gut lining.
Also entoderm.

Origin of endoderm

1825–35; < French endoderme; see endo-, -derm
Related formsen·do·der·mal, en·do·der·mic, adjective
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

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British Dictionary definitions for endoderm



  1. the inner germ layer of an animal embryo, which gives rise to the lining of the digestive and respiratory tractsSee also ectoderm, mesoderm
Derived Formsendodermal, endodermic, entodermal or entodermic, adjective
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Word Origin and History for endoderm

1835, from endo- + -derm. Coined by Prussian embryologist Robert Remak (1815-1865).

Online Etymology Dictionary, © 2010 Douglas Harper

endoderm in Medicine


  1. The innermost of the three primary germ layers of an embryo, developing into the gastrointestinal tract, the lungs, and associated structures.hypoblast
Related formsen′do•dermal adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

endoderm in Science


  1. The innermost of the primary germ layers of an animal embryo. In vertebrates, the endoderm gives rise to the respiratory tract, gastrointestinal tract (except mouth and anus), glands associated with the gastrointestinal tract, bladder, and urethra. Compare ectoderm mesoderm.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.