endorphins

Cultural  

1. Substances produced by the brain that have painkilling and tranquillizing effects on the body. Endorphins are thought to be similar to morphine and are usually released by the brain during times of extreme body stress. The release of endorphins may explain why trauma victims sometimes cannot feel the pain associated with their injuries.

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Example Sentences

Researchers in the late 1970s found that after patients had their molars extracted, an IV saline drip provided pain relief through the body’s natural ability to produce endorphins.

From Slate • Jan. 30, 2026

Cardio is not just good for my heart, but is a great emotional release and gets my endorphins going.

From The Wall Street Journal • Jan. 5, 2026

Immunologist professor Eleanor Riley tells BBC Radio 4's Inside Health podcast that the post-swim "high" is real, but it's driven by adrenaline and endorphins.

From BBC • Nov. 21, 2025

The runner’s high — which can occur with any form of exercise — was originally thought to be caused by the release of feel-good hormones called endorphins after a high intensity workout.

From Salon • Apr. 19, 2025

Basketball and Erin make the rest of the world go away—focus me, make me forget, and get the endorphins flowing.

From "Boy21" by Matthew Quick