epigenome

American  

[ep-i-jee-nohm] / ˌɛp ɪˈdʒi noʊm /

noun

1. Genetics. a network of chemical compounds surrounding DNA that modify the genome without altering the DNA sequences and have a role in determining which genes are active in a particular cell.

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Etymology

Origin of epigenome

epi- + genome

Example Sentences

Dr. Ramy Saad, lead researcher at King's College London and also affiliated with University College London as a doctor in Clinical Genetics, said: "This is a very exciting finding, and the next important questions are what is behind this association and how can we explore the interactions between dietary metabolites and our epigenome further? This approach could lead us to important discoveries towards aging, and beyond, in common and rare diseases."

From Science Daily

The researchers believe that combining immunotherapy with drugs that modify the epigenome could improve treatment outcomes.

From Science Daily

Besides the pure characterisation of the malignant cells' epigenome, the study also cross-referenced the epigenetic data with information on the sensitivity of over 300 drugs, so "now, a separate algorithm can predict which epigenetic lesion is associated with sensitivity or resistance to a medication", an important milestone for clinical research according to Dr. Esteller.

From Science Daily

By studying mice with heart failure, the researchers found evidence of stress imprinting on the epigenome, that is, chemical changes occurred to the mice's DNA.

From Science Daily

"In animals with heart failure, supplementing additional active TGF-β has been shown to be a potential treatment. Correcting the epigenome of hematopoietic stem cells could also be a way to deplete stress memory."

From Science Daily