epigenome

[ep-i-jee-nohm]

noun

1. Genetics.,  a network of chemical compounds surrounding DNA that modify the genome without altering the DNA sequences and have a role in determining which genes are active in a particular cell.

Word History and Origins

Origin of epigenome¹

epi- + genome

Example Sentences

The researchers believe that combining immunotherapy with drugs that modify the epigenome could improve treatment outcomes.

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Besides the pure characterisation of the malignant cells' epigenome, the study also cross-referenced the epigenetic data with information on the sensitivity of over 300 drugs, so "now, a separate algorithm can predict which epigenetic lesion is associated with sensitivity or resistance to a medication", an important milestone for clinical research according to Dr. Esteller.

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By studying mice with heart failure, the researchers found evidence of stress imprinting on the epigenome, that is, chemical changes occurred to the mice's DNA.

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"In animals with heart failure, supplementing additional active TGF-β has been shown to be a potential treatment. Correcting the epigenome of hematopoietic stem cells could also be a way to deplete stress memory."

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"You can't necessarily reverse genetic mutations, but when you know disease risks result from changes in the epigenome you can potentially negate them."

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