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epitope

American  
[ep-i-tohp] / ˈɛp ɪˌtoʊp /

noun

Immunology.
  1. determinant.


epitope British  
/ ˈɛpɪˌtəʊp /

noun

  1. the site on an antigen at which a specific antibody becomes attached

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of epitope

epi- + -tope, from Greek tópos “place”; cf. topo-

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The translocatable Tmab-PMPC100 was the best at efficient blood-brain barrier penetration while retaining trastuzumab's epitope recognition, the ability of the antibody to bind to its antigen target.

From Science Daily Jan. 3, 2024

The word "epitope" means the substance that the immune system recognizes and protects against.

From Salon Aug. 10, 2022

Others, such as epitope tagging, use antibodies to track marked proteins, revealing their location and abundance in cells and providing hints about their function.

From Science Magazine Jul. 21, 2022

Note that recognition occurs at a specific epitope rather than on the entire antigen; for this reason, epitopes are known as “antigenic determinants.”

From Textbooks Jun. 9, 2022

This mAb, derived from B cells of a patient who recovered from SARS-1 in 2003, targets an epitope on the S protein that is conserved in the sarbecovirus family.

From Scientific American Jan. 6, 2022

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