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epitope

American  
[ep-i-tohp] / ˈɛp ɪˌtoʊp /

noun

Immunology.
  1. determinant.


epitope British  
/ ˈɛpɪˌtəʊp /

noun

  1. the site on an antigen at which a specific antibody becomes attached

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of epitope

epi- + -tope, from Greek tópos “place”; cf. topo-

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

In fact, the study showed tumors with a mutated version of the epitope of Fas receptors will not respond to CAR T at all.

From Science Daily • Oct. 23, 2023

The word "epitope" means the substance that the immune system recognizes and protects against.

From Salon • Aug. 10, 2022

Others, such as epitope tagging, use antibodies to track marked proteins, revealing their location and abundance in cells and providing hints about their function.

From Science Magazine • Jul. 21, 2022

Note that recognition occurs at a specific epitope rather than on the entire antigen; for this reason, epitopes are known as “antigenic determinants.”

From Textbooks • Jun. 9, 2022

Adagio’s lead antibody, ADG20, was among a group isolated from a convalescent SARS-1 donor, and targets a conserved epitope on the S protein present on all SARS-1, SARS-2 and many potential emergent bat viruses.

From Scientific American • Jan. 6, 2022

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