fumarate

American  

[fyoo-muh-reyt] / ˈfyu məˌreɪt /

noun

Biochemistry.

1. the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.

---

fumarate Scientific  

/ fyo̅o̅′mə-rāt′ /

1. A salt or ester of fumaric acid, in which one or both of the hydrogen atoms in the carboxyl groups of the fumaric acid have been replaced with another element or group.

---

Etymology

Origin of fumarate

First recorded in 1860–65; fumar(ic acid) + -ate ²

Example Sentences

The discovery that fumarate rescues aging T-cells from excessive mitochondrial loss and enhances their anti-tumor activity suggests another way to protect immune health.

From Science Daily • Oct. 10, 2025

The results also revealed that amyloid beta contributes to cancer in another way - by depleting fumarate, a small molecule made inside mitochondria during energy production.

From Science Daily • Oct. 10, 2025

Pre-exposure prophylaxis, known as PrEP, is a combination of two drugs — tenofovir disoproxil fumarate and emtricitabine — made by Gilead Sciences and marketed as Truvada.

From Washington Post • Nov. 20, 2018

In April, Yaghi's group, along with that of M.I.T. mechanical engineer Evelyn Wang, reported on a prototype device incorporating MOF-801, or zirconium fumarate, which has a high affinity for water.

From Scientific American • Nov. 14, 2017

It is a yellowish oil which melts at -24� C.; it boils at 143-144� C., but cannot be distilled safely as it decomposes violently, giving nitrogen and ethyl fumarate.

From Encyclopaedia Britannica, 11th Edition, Volume 8, Slice 4 "Diameter" to "Dinarchus" by Various