fumarate

[fyoo-muh-reyt]

noun

Biochemistry.

1. the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.

fumarate

1. A salt or ester of fumaric acid, in which one or both of the hydrogen atoms in the carboxyl groups of the fumaric acid have been replaced with another element or group.

Word History and Origins

Origin of fumarate¹

First recorded in 1860–65; fumar(ic acid) + -ate ²

Example Sentences

The results also revealed that amyloid beta contributes to cancer in another way - by depleting fumarate, a small molecule made inside mitochondria during energy production.

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Fumarate acts like a brake, keeping mitophagy from running out of control.

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When fumarate levels drop, cells recycle too many of their healthy mitochondria, resulting in a loss of strength.

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"When you deplete fumarate, you increase mitophagy much more," Ogretmen explained.

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"Fumarate no longer binds proteins involved in that process, so the proteins become more active and induce more mitophagy. It's like a reinforcing feedback loop."

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