fumarate

American  

[fyoo-muh-reyt] / ˈfyu məˌreɪt /

noun

Biochemistry.

1. the salt of fumaric acid, a key chemical intermediate in the Krebs cycle.

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fumarate Scientific  

/ fyo̅o̅′mə-rāt′ /

1. A salt or ester of fumaric acid, in which one or both of the hydrogen atoms in the carboxyl groups of the fumaric acid have been replaced with another element or group.

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Etymology

Origin of fumarate

First recorded in 1860–65; fumar(ic acid) + -ate ²

Example Sentences

The results also revealed that amyloid beta contributes to cancer in another way - by depleting fumarate, a small molecule made inside mitochondria during energy production.

From Science Daily

Fumarate acts like a brake, keeping mitophagy from running out of control.

From Science Daily

When fumarate levels drop, cells recycle too many of their healthy mitochondria, resulting in a loss of strength.

From Science Daily

"When you deplete fumarate, you increase mitophagy much more," Ogretmen explained.

From Science Daily

"Fumarate no longer binds proteins involved in that process, so the proteins become more active and induce more mitophagy. It's like a reinforcing feedback loop."

From Science Daily