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gangrene

American  
[gang-green, gang-green] / ˈgæŋ grin, gæŋˈgrin /

noun

  • gangrenes
    plural
  1. necrosis or death of soft tissue due to obstructed circulation, usually followed by decomposition and putrefaction.

  2. moral or spiritual corruption and decadence that pervades an individual or group.

    “This church body has been afflicted with a spiritual gangrene that is poisoning our relationship with the Lord,” the preacher expostulated.

    Synonyms:
    degeneracy, depravity, rot, decay

verb (used with or without object)

  • gangrenes,
    present (3rd person singular)
  • gangrened,
    past participle,  past
  • gangrening
    present participle
  1. to affect or become affected with gangrene.

gangrene British  
/ ˈɡæŋɡriːn /

noun

  1. death and decay of tissue as the result of interrupted blood supply, disease, or injury

  2. moral decay or corruption

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to become or cause to become affected with gangrene

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
gangrene Scientific  
/ gănggrēn′ /
  1. Death of tissue in a living body, especially in a limb, caused by a bacterial infection resulting from a blockage of the blood supply to the affected tissue.


gangrene Cultural  
  1. The death and decay of body tissue owing to insufficient supply of blood.


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Etymology

Origin of gangrene

First recorded in 1535–45; from Middle French gangrene (earlier cancrene ), from Latin gangraena, from Greek gángraina “an eating sore”

Compare meaning

How does gangrene compare to similar and commonly confused words? Explore the most common comparisons:

Explanation

You don't want gangrene, that's for sure. It's the infection that can develop around a wound that kills the tissue, turning it into a terrible stinking sore. In the days before antibiotics even the smallest scratch could lead to gangrene, and doctors would often cut off a finger or even a limb and then seal it with a red hot poker rather than risk the infection spreading. Special surgeons known as sawbones were famed for the speed they could amputate a limb to avoid gangrene setting in. Enough to stop you ever being nostalgic about the good old days.

Keep Reading on Vocabulary.com

Vocabulary lists containing gangrene

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

He has consulted fellow Spaniard Santi Cazorla, who was sidelined for 636 days after gangrene ravaged his Achilles tendon, and takes inspiration from the former Arsenal midfielder's comeback.

From BBC Feb. 15, 2026

To really investigate gangrene, he would need to go where infection was far more plentiful; not the battlefield, but the hospital.

From The Wall Street Journal Feb. 6, 2026

Nursing employees told the investigators that the 69-year-old man, who had been admitted with gangrene on his feet, was often confused and sometimes tried to pull out his tubes.

From Los Angeles Times Mar. 20, 2025

By World War II, even as scientists were manufacturing gallons of phages to combat cholera, dysentery, and gangrene in Stalingrad and Leningrad, much the West had given up on phages.

From Salon Nov. 20, 2024

If I can’t quite get the hang of poverty-chastity-and-obedience, I can learn instead about vermifuges, breech deliveries, arrow wounds, gangrene, and elephantiasis.

From "The Poisonwood Bible" by Barbara Kingsolver

Oftener than not it gangrenes, and there is loss of sound tissue and the setting-up of strange and malevolent growth.

From The Quickening by E. M. Ashe

But there come gangrenes in the heart, or perhaps in the pocket.

From Dr. Wortle's School by Anthony Trollope

The swellings of the tonsils are sensible to the eye and touch externally, and have an elastic rather than an œdematous feel, like parts in the vicinity of gangrenes.

From Zoonomia, Vol. II Or, the Laws of Organic Life by Erasmus Darwin

Fabricius takes the occasion to give a caution to young surgeons, to avoid being too sanguine in predicting recovery from gangrenes.

From North American Medical and Surgical Journal, Vol. 2, No. 3, July, 1826 by Franklin Bache

Crutches, and itches, and leprosies, and ulcers, and gangrenes, and running sores, praise ye the Lord, for to-night ye have saved our Archbishop! 1ST BEGGAR.

From Becket and other plays by Alfred Tennyson, Baron Tennyson

One man came limping in, unassisted, on a gangrened leg teeming with worms.

From "Kaffir Boy: An Autobiography" by Mark Mathabane

If you'd seen her and lived with her as I have, year out and year in, you'd know her love of money has eat into her soul and gangrened it.

From Flamsted quarries by G. Patrick Nelson

The doctors tell me that many slight wounds have gangrened owing to the cold.

From Diary of the Besieged Resident in Paris by Henry Labouchere

The wounded men who were not gangrened were carefully kept apart from those who were.

From Memories A Record of Personal Experience and Adventure During Four Years of War by Fannie A. Beers

Here we see both what he calls his "gangrened sensibility" and a complete abandonment to the feelings of the moment.

From Poems of Coleridge by Arthur Symons

It drags upon me like a prisoner's gangrening fetter, and I'm getting tired of it.

From To-morrow? by Victoria Cross

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