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Synonyms

gangrene

American  
[gang-green, gang-green] / ˈgæŋ grin, gæŋˈgrin /

noun

  • gangrenes
    plural
  1. necrosis or death of soft tissue due to obstructed circulation, usually followed by decomposition and putrefaction.

  2. moral or spiritual corruption and decadence that pervades an individual or group.

    “This church body has been afflicted with a spiritual gangrene that is poisoning our relationship with the Lord,” the preacher expostulated.

    Synonyms:
    degeneracy, depravity, rot, decay

verb (used with or without object)

  • gangrenes,
    present (3rd person singular)
  • gangrened,
    past participle,  past
  • gangrening
    present participle
  1. to affect or become affected with gangrene.

gangrene British  
/ ˈɡæŋɡriːn /

noun

  1. death and decay of tissue as the result of interrupted blood supply, disease, or injury

  2. moral decay or corruption

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to become or cause to become affected with gangrene

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
gangrene Scientific  
/ găng′grēn′ /
  1. Death of tissue in a living body, especially in a limb, caused by a bacterial infection resulting from a blockage of the blood supply to the affected tissue.


gangrene Cultural  
  1. The death and decay of body tissue owing to insufficient supply of blood.


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Etymology

Origin of gangrene

First recorded in 1535–45; from Middle French gangrene (earlier cancrene ), from Latin gangraena, from Greek gángraina “an eating sore”

Compare meaning

How does gangrene compare to similar and commonly confused words? Explore the most common comparisons:

Explanation

You don't want gangrene, that's for sure. It's the infection that can develop around a wound that kills the tissue, turning it into a terrible stinking sore. In the days before antibiotics even the smallest scratch could lead to gangrene, and doctors would often cut off a finger or even a limb and then seal it with a red hot poker rather than risk the infection spreading. Special surgeons known as sawbones were famed for the speed they could amputate a limb to avoid gangrene setting in. Enough to stop you ever being nostalgic about the good old days.

Keep Reading on Vocabulary.com

Vocabulary lists containing gangrene

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

He learned to patch up injured men in below-deck sea cabins, where gangrene turned a wound black and rotten.

From The Wall Street Journal ● Feb. 6, 2026

On 28 June, the family were told Mr Trotter had a condition called Fournier's gangrene and nothing more could be done.

From BBC ● Jan. 20, 2026

Nursing employees told the investigators that the 69-year-old man, who had been admitted with gangrene on his feet, was often confused and sometimes tried to pull out his tubes.

From Los Angeles Times ● Mar. 20, 2025

Her lower legs were amputated after she developed gangrene at age 7.

From Seattle Times ● May 15, 2024

The doctor tells Mr. Hannon he has to go to the hospital or it’s a case of gangrene he’ll have and the doctor won’t be responsible.

From "Angela's Ashes: A Memoir" by Frank McCourt

For fungous flesh, it promotes discharge, and destroys both gangrenes and carbuncles.

From The Leper in England: with some account of English lazar-houses by Robert Charles Hope

The 'mind,' somehow, causes gangrenes, if not cancers, paralysis, shrinking of tissues; the mind, somehow, cures them.

From The Making of Religion by Andrew Lang

Oftener than not it gangrenes, and there is loss of sound tissue and the setting-up of strange and malevolent growth.

From The Quickening by E. M. Ashe

Crutches, and itches, and leprosies, and ulcers, and gangrenes, and running sores, praise ye the Lord, for to-night ye have saved our Archbishop! 1ST BEGGAR.

From Becket and other plays by Alfred Tennyson, Baron Tennyson

Fabricius takes the occasion to give a caution to young surgeons, to avoid being too sanguine in predicting recovery from gangrenes.

From North American Medical and Surgical Journal, Vol. 2, No. 3, July, 1826 by Franklin Bache

One man came limping in, unassisted, on a gangrened leg teeming with worms.

From "Kaffir Boy: An Autobiography" by Mark Mathabane

Its leather was dry-rotted with age and the brass C. S. A. on the outer flap was gangrened and sunken in; the flap curled up stiffly, like an old shoe sole.

From The Escape of Mr. Trimm His Plight and other Plights by Irvin S. (Irvin Shrewsbury) Cobb

The convention," said Robespierre, in his reply to the deputation, "in the situation in which it now stands, gangrened by corruption, and being wholly unable to recover itself, cannot save the republic-both must perish.

From History of the French Revolution from 1789 to 1814 by M. (François-Auguste-Marie-Alexis) Mignet

Were half my body gangrened, I would not smite nor reproach it, but seek with patience an available remedy.

From A Trip to Cuba by Julia Ward Howe

Agathocles, the tyrant of Syracuse, was given by the treacherous Maenon a poisoned toothpick which soon rendered his mouth incurably gangrened, and deprived him of the power of speech.

From The Last Words of Distinguished Men and Women (Real and Traditional) by Frederic Rowland Marvin

It drags upon me like a prisoner's gangrening fetter, and I'm getting tired of it.

From To-morrow? by Victoria Cross

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