Regardless of, in defiance of, as in They kept on in spite of their fears. [c. 1400]
The American Heritage® Idioms Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
How to use in spite of in a sentence
She looks like one of the do-as-I-please-in-spite-of-you kind.Grace Harlowe's Third Year at Overton College | Jessie Graham Flower