isolate

American  

[ahy-suh-leyt, ahy-suh-lit, -leyt] / ˈaɪ səˌleɪt, ˈaɪ sə lɪt, -ˌleɪt /

verb (used with object)

isolated, isolating

1. to set or place apart; detach or separate so as to be alone.

2. Medicine/Medical. to keep (an infected person) from contact with noninfected persons; quarantine.

3. Chemistry, Bacteriology. to obtain (a substance or microorganism) in an uncombined or pure state.

4. Electricity. to insulate.

5. Television. to single out (a person, action, etc.) for a camera closeup.

---

noun

1. a person, thing, or group that is set apart or isolated, as for purposes of study.

2. Psychology. a person, often shy or lacking in social skills, who avoids the company of others and has no friends within a group.

3. Biology. an inbreeding population that is isolated from similar populations by physiological, behavioral, or geographic barriers.

4. Also called language isolate.  Linguistics. a language with no demonstrable genetic relationship, as Basque.

5. something that has been isolated, as a by-product in a manufacturing process.

   an isolate of soy flour.

adjective

1. isolated; alone.

isolate British  

verb

1. to place apart; cause to be alone

2. med to quarantine (a person or animal) having or suspected of having a contagious disease

3. to obtain (a compound) in an uncombined form

4. to obtain pure cultures of (bacteria, esp those causing a particular disease)

5. electronics to prevent interaction between (circuits, components, etc); insulate

---

noun

1. an isolated person or group

Other Word Forms

• isolability noun
• isolable adjective
• isolator noun
• reisolate verb (used with object)
• unisolate verb (used with object)

Etymology

Origin of isolate

First recorded in 1800–10; back formation from isolated

Explanation

When you remove or set apart one thing from others, you isolate it. You could isolate yourself from people by living in a remote hut or, if you're a biologist, you could isolate a chromosome. The verb isolate comes from the adjective isolated, which comes from the Latin insulatas, meaning “made into an island.” You may have heard the John Donne quote, “No man is an island.” Donne was claiming that no matter how much you might try to isolate yourself from the rest of humanity, in the end people are all connected to one another. Humanity’s need for connectedness may, in fact, be illustrated by the fact that jailers frequently isolate criminals as punishment.

Example Sentences

South Carolina has reported around 670 cases of the virus that have forced hundreds to quarantine or isolate.

From Salon • Apr. 22, 2026

To isolate the issue, Duffy and Li designed a controlled experiment with people ages 45 to 55.

From MarketWatch • Apr. 16, 2026

Researchers then isolate these synapses and use high-throughput sequencing to read which barcode pairs are found together.

From Science Daily • Apr. 7, 2026

A workaround was found to isolate the batteries from the vibration, which allowed the car to run for longer.

From BBC • Mar. 19, 2026

“You will be in combat, but perhaps not always on the front line. If one can even isolate a front line in this type of war,” says Plutarch.

From "Mockingjay" by Suzanne Collins

Related Words

• confine
• detach
• disconnect
• disengage
• divide
• insulate
• remove
• segregate
• separate
• sequester