Lewy bodies

/ ˈluːɪ /

plural noun

1. abnormal proteins that occur in the nerve cells of the cerebral cortex and the basal ganglia, causing Parkinson's disease and dementia

Word History and Origins

Origin of Lewy bodies¹

C20: named after F. H. Lewy (1885–1950), German neurologist

Example Sentences

For over a century, doctors have identified Parkinson's by the presence of large protein deposits known as Lewy bodies.

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"Lewy bodies are the hallmark of Parkinson's, but they essentially tell you where the disease has been, not where it is right now," said Professor Steven Lee from Cambridge's Yusuf Hamied Department of Chemistry, who co-led the research.

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As the protein builds up, it forms clumps known as "Lewy" bodies that are a pathological hallmark of Parkinson's disease.

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When proteins misfold, they can form abnormal clusters called Lewy bodies, which build up within brain cells stopping them from functioning properly.

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A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias.

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