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mainline

American  
[meyn-lahyn, -lahyn] / ˈmeɪnˌlaɪn, -ˈlaɪn /

verb (used without object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject a narcotic, especially heroin, directly into a vein.

  2. to use or enjoy something without restriction.

    to mainline on TV movies.


verb (used with object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject (a narcotic, especially heroin) directly into a vein.

  2. to use, enjoy, or imbibe (something) without restriction.

    mainlining coffee all day long.

adjective

  1. having a principal, established, or widely accepted position; major; mainstream.

    the membership of mainline churches.

Other Word Forms

Inflected Forms

Participles

Conjugated Forms

Present

Past

Future

Etymology

Origin of mainline

1935–40, v., adj. use of main line

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Located above a busy mainline railway station, MSG is slap bang in the beating heart of tourist and commercial Manhattan.

From Barron's • Jul. 1, 2026

The mainline is a collection of long-established Protestant denominations: the Episcopalians, United Methodists, Presbyterians and so on.

From The Wall Street Journal • Jun. 25, 2026

The news has sparked excitement and discussion among fans, particularly around the next mainline entry starring a woman.

From BBC • Jun. 3, 2026

The airline’s cancellations related to pilot availability are more than 10 times historical levels, and account for 35% of its mainline flight cancellations.

From The Wall Street Journal • May 26, 2026

Like many other evangelicals, some members attend churches that adhere to evangelical doctrine but that remain affiliated with mainline denominations.

From "Class Matters" by The New York Times

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