major histocompatibility complex

noun

Immunology.

1. MHC.

major histocompatibility complex

noun

1. the full name for MHC

major histocompatibility complex

1. A group of genes that code for cell-surface histocompatibility antigens and are the principal determinants of tissue type and transplant compatibility. They are the most diverse genes in humans and are used to determine if a sample of DNA comes from a specific person.

Example Sentences

Researchers believe that a particular group of genes, the major histocompatibility complex, play a large role in scent production.

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Approximately 65% of elite controllers carry a particular variant of the human leukocyte antigen B gene, which is located in the major histocompatibility complex region, a part of our DNA that controls the adaptive immune response to pathogens and other threats.

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Doherty won the Nobel Prize for medicine in 1996 with his Swiss colleague Rolf Zinkernagel for “their discoveries concerning the specificity of the cell-mediated immune defence and the biological role of the major histocompatibility complex”.

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One possibility is to use gene editing to remove the markers on transplanted cells, called the major histocompatibility complex, that red-flag them for the host’s immune system.

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A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.

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