verb (used with object), meth·yl·at·ed, meth·yl·at·ing.
  1. (in a compound) to replace (one or more hydrogen atoms) with the methyl group.
  2. to mix with methyl alcohol, as in the denaturation of ethyl alcohol.

Origin of methylate

First recorded in 1825–35; methyl- + -ate1
Related formsmeth·yl·a·tor, nounun·meth·yl·at·ed, adjective Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for methylate

Historical Examples of methylate

British Dictionary definitions for methylate


  1. (tr) to mix with methanol
  2. to undergo or cause to undergo a chemical reaction in which a methyl group is introduced into a molecule
  1. another name for methoxide
Derived Formsmethylation, nounmethylator, noun
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

methylate in Medicine


  1. To mix or combine with methyl alcohol.
  2. To combine with the methyl radical.
  1. An organic compound in which the hydrogen of the hydroxyl group of methyl alcohol is replaced by a metal.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

methylate in Science


  1. An organic compound having the general formula CH3OR, in which R is a metal. Methylates are formed by replacing the hydrogen of the hydroxyl group (OH) of methyl alcohol with a metal.
  1. To combine with the methyl radical.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.