• synonyms


  1. Also called methoxide. any derivative of methyl alcohol, as sodium methylate, CH3ONa.
  2. any compound containing the methyl group.
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verb (used with object), meth·yl·at·ed, meth·yl·at·ing.
  1. (in a compound) to replace (one or more hydrogen atoms) with the methyl group.
  2. to mix with methyl alcohol, as in the denaturation of ethyl alcohol.
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Origin of methylate

First recorded in 1825–35; methyl- + -ate1
Related formsmeth·yl·a·tor, nounun·meth·yl·at·ed, adjective
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for methylate

Historical Examples of methylate

  • Last night, however, I managed to secure and methylate a good-sized scorpion.

    Australia Twice Traversed, The Romance of Exploration

    Ernest Giles

  • They form unstable addition products with sodium ethylate or methylate.

  • The latter is then made to methylate a product, aniline, derived indirectly from coal-tar.


    Raphael Meldola

British Dictionary definitions for methylate


  1. (tr) to mix with methanol
  2. to undergo or cause to undergo a chemical reaction in which a methyl group is introduced into a molecule
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  1. another name for methoxide
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Derived Formsmethylation, nounmethylator, noun
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

methylate in Medicine


  1. To mix or combine with methyl alcohol.
  2. To combine with the methyl radical.
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  1. An organic compound in which the hydrogen of the hydroxyl group of methyl alcohol is replaced by a metal.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

methylate in Science


  1. An organic compound having the general formula CH3OR, in which R is a metal. Methylates are formed by replacing the hydrogen of the hydroxyl group (OH) of methyl alcohol with a metal.
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  1. To combine with the methyl radical.
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The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.