Misy when it effloresces in no great quantity from the others is like a kind of pollen, otherwise it is nodular.
The granulations about the margins become large, red, nodular, hard and bleed very readily.
The infiltrating cancer begins as an elevation of the skin, which progresses until it becomes rough and nodular.
While in the nodular stage the affection is sometimes painful, but with the formation of the ulcer the pain subsides.
This may be seen especially at Goslar, where the nodular lumps of dark grey colour are called vitriol stone (lapis atramenti).
