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painkiller

American  
[peyn-kil-er] / ˈpeɪnˌkɪl ər /

noun

  • painkillers
    plural
  1. a drug, treatment, or anything else that relieves pain, especially an analgesic.


painkiller British  
/ ˈpeɪnˌkɪlə /

noun

  1. an analgesic drug or agent

  2. anything that relieves pain

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Derived Forms

Inflected Forms

Nouns

Etymology

Origin of painkiller

An Americanism dating back to 1850–55; pain + killer

Explanation

A painkiller is a medicine that's used to dull or relieve pain, like the painkiller your dad gives you when you have a bad headache. Painkillers are meant to do exactly what their name says: to kill pain. You can also call this kind of medication an analgesic. These range from aspirin and acetaminophen, which are sold over the counter to treat minor aches and pains, to powerful anesthetics administered by doctors before surgery. If you get your wisdom teeth removed, you'll most likely need a painkiller during and after the procedure.

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Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Scientific research has not identified causality between taking the painkiller and the development of those conditions in children.

From Barron's Jul. 13, 2026

The painkiller is usually prescribed for relatively minor conditions, such as aching joints or people recovering from surgery.

From The Wall Street Journal Jul. 12, 2026

A decade of loyalty card data across 211 million transactions in an unnamed chain of high street stores in England found paracetamol was the most common painkiller bought alongside tampons and sanitary towels.

From BBC Jun. 14, 2026

He previously wrote about Samsung from Seoul, but in prior stints at the Journal's New York, Atlanta and Chicago offices, he covered Wall Street's biggest buyers, painkiller addiction, airlines and food.

From The Wall Street Journal Jan. 31, 2026

“Mom said you should remember to take your painkiller, Kambili,” she said.

From "Purple Hibiscus" by Chimamanda Ngozi Adichie

Josh said the GP "found nothing wrong", prescribing more painkillers and referring him to an optician, where again no issue was found.

From BBC Jul. 28, 2026

In Pasadena, volunteers at the restaurant Chamo Venezuelan Cuisine collected supplies, issuing a special plea for bandages, gauze, painkillers and other over-the-counter medicines.

From Los Angeles Times Jun. 29, 2026

The deal includes 4E’s pipeline of oral MNK inhibitors, an emerging class of non-opioid painkillers that target a biological pathway within a patient’s nerve endings to stop the generation of pain signals.

From Barron's Jun. 16, 2026

Kevin Liu, an oil and gas analyst with Bloomberg Intelligence, compared the SPR releases as a painkillers for the oil market.

From MarketWatch May 28, 2026

Every once in a while, especially as it got later and her last dose of painkillers wore off, she would flinch for a second, but her eyes never lost the intensity I had noticed earlier.

From "Drums, Girls, and Dangerous Pie" by Jordan Sonnenblick

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