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Synonyms

painkiller

American  
[peyn-kil-er] / ˈpeɪnˌkɪl ər /

noun

  1. a drug, treatment, or anything else that relieves pain, especially an analgesic.


painkiller British  
/ ˈpeɪnˌkɪlə /

noun

  1. an analgesic drug or agent

  2. anything that relieves pain

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • painkilling adjective

Etymology

Origin of painkiller

An Americanism dating back to 1850–55; pain + killer

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Wall Street has been focusing on the company’s next-generation painkiller Journavax, as well as its IgA nephropathy treatment.

From Barron's • Mar. 10, 2026

He previously wrote about Samsung from Seoul, but in prior stints at the Journal's New York, Atlanta and Chicago offices, he covered Wall Street's biggest buyers, painkiller addiction, airlines and food.

From The Wall Street Journal • Jan. 31, 2026

The idea that a humble painkiller could help prevent cancer is both exciting and provocative.

From Science Daily • Jan. 20, 2026

This reinforces guidance from major medical organisations in the UK, US and Europe on the safety of the common painkiller.

From BBC • Jan. 16, 2026

If Henry had been suffering from poison ivy, hay fever, rheumatism, pinkeye, we would have been in luck but the only painkiller they had was Excedrin.

From "The Secret History" by Donna Tartt