proband

American  

[proh-band] / ˈproʊ bænd /

noun

Genetics.

1. a patient who is the initial member of a family to come under study.

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proband British  

/ ˈprəʊbænd /

noun

1. another name (esp US) for propositus

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Etymology

Origin of proband

1925–30; < Latin probandus, gerundive of probāre to test, probe

Example Sentences

Granddaddy called it the Proband.

From Literature

For cases in which there is a single affected proband and no family history, investigators should consider sequencing the unaffected parents of the probands, permitting efficient discovery of de novo mutations and compound heterozygous genotypes.

From Nature

Upon further medical evaluation, these mutations were found to account for each proband’s disease, leading to a change in diagnosis, some of which led to changes in patient management.

From Science Magazine

Australian pedigrees for which the proband was identified as carrying the E318K variant via Sequenom, as well as the panel of melanoma cell lines, were screened for E318K via Sanger sequencing using the following primers: forward, 5′-CAGGCTCGAGCTCATGGA-3′; reverse, 5′- TGGGGACACTATAGGCTTGG-3′.

From Nature

If he fled from his lord's service, or from the land which he held, a writ issued de nativitate proband�, and the master recovered his fugitive by law.

From Project Gutenberg