proband

[proh-band]

noun

Genetics.

1. a patient who is the initial member of a family to come under study.

proband

/ ˈprəʊbænd /

noun

1. another name (esp US) for propositus

Word History and Origins

Origin of proband¹

1925–30; < Latin probandus, gerundive of probāre to test, probe

Word History and Origins

Origin of proband¹

C20: from Latin probandus, gerundive of probāre to test

Example Sentences

Granddaddy called it the Proband.

Read more on Literature

For cases in which there is a single affected proband and no family history, investigators should consider sequencing the unaffected parents of the probands, permitting efficient discovery of de novo mutations and compound heterozygous genotypes.

Read more on Nature

Upon further medical evaluation, these mutations were found to account for each proband’s disease, leading to a change in diagnosis, some of which led to changes in patient management.

Read more on Science Magazine

Australian pedigrees for which the proband was identified as carrying the E318K variant via Sequenom, as well as the panel of melanoma cell lines, were screened for E318K via Sanger sequencing using the following primers: forward, 5′-CAGGCTCGAGCTCATGGA-3′; reverse, 5′- TGGGGACACTATAGGCTTGG-3′.

Read more on Nature

If he fled from his lord's service, or from the land which he held, a writ issued de nativitate proband�, and the master recovered his fugitive by law.

Read more on Project Gutenberg