No difference at all, the same thing, as in She's my sister, or stepsister—same difference. This jocular colloquial phrase dates from about 1940.
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How to use same difference in a sentence
None of these, though, has inspired quite the same backlash as fluoride.
This same outlet worked the phrase “engagement to toyboy lover” into the headline of their article on Fry.
It is the summit of human happiness: the surrender of man to God, of woman to man, of several women to the same man.Houellebecq’s Incendiary Novel Imagines France With a Muslim President|Pierre Assouline|January 9, 2015|DAILY BEAST
To those who agreed with him, Bush pledged that the law against same-sex marriage would remain intact.
For his part, Bratton is disappointed but not surprised that the same narrative is already being mapped onto Fry and Spencer.
I waited three months more, in great impatience, then sent him back to the same post, to see if there might be a reply.The Boarded-Up House|Augusta Huiell Seaman
The Pontellier and Ratignolle compartments adjoined one another under the same roof.The Awakening and Selected Short Stories|Kate Chopin
On the thirteenth of the same month they bound to the stake, in order to burn alive, a man who had two religious in his house.
Some were even re-arrested for the same nefarious purpose, and the daily papers published their names on each occasion.The Philippine Islands|John Foreman
The tenor dies; the prima donna appears to do the same, but the libretto consoles you by declaring that she only swoons.Physiology of The Opera|John H. Swaby (AKA "Scrici")