sclerosis

American  

[skli-roh-sis] / sklɪˈroʊ sɪs /

noun

plural

scleroses

1. Pathology. a hardening or induration of a tissue or part, or an increase of connective tissue or the like at the expense of more active tissue.

2. Botany. a hardening of a tissue or cell wall by thickening or lignification.

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sclerosis British  

/ sklɪəˈrəʊsɪs /

noun

1. pathol a hardening or thickening of organs, tissues, or vessels from chronic inflammation, abnormal growth of fibrous tissue, or degeneration of the myelin sheath of nerve fibres, or (esp on the inner walls of arteries) deposition of fatty plaques Compare arteriosclerosis atherosclerosis multiple sclerosis

2. the hardening of a plant cell wall or tissue by the deposition of lignin

3. a debilitating lack of progress or innovation within an institution or organization

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Other Word Forms

• sclerosal adjective

Etymology

Origin of sclerosis

1350–1400; Middle English < Medieval Latin < Greek sklḗrōsis hardening. See scler-, -osis

Example Sentences

The launch of generic treatments in the U.S. for psoriasis, osteoporosis and multiple sclerosis helped to boost 2025 revenue.

From The Wall Street Journal

Actor Eric Dane, who rose to fame as Dr. Mark Sloan on “Grey’s Anatomy,” died Thursday afternoon following a battle with amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease.

From Salon

It makes for a wily and endearing tale, and in Adrian Nathan West’s excellent translation, the writing is remarkably untroubled by the stylistic sclerosis that can afflict writers with Vargas Llosa’s prestige.

From The Wall Street Journal

A former competitive swimmer and water polo player, he said ALS — also known as amyotrophic lateral sclerosis or Lou Gehrig’s disease — initially caused the right side of his body to stop working.

From Los Angeles Times

The dataset included healthy individuals as well as people diagnosed with 13 different diseases, including Crohn's disease, colorectal cancer, Parkinson's disease, and multiple sclerosis.

From Science Daily