sickle cell anemia
Origin of sickle cell anemia
Words nearby sickle cell anemia
How to use sickle cell anemia in a sentence
Researchers have shown its potential for reversing blindness and sickle cell anemia, and to treat genetic diseases in animals.MRNA's Next Chapter Has Nothing to Do With COVID-19 Vaccines|Jamie Ducharme|August 2, 2021|Time
In the case of sickle cell anemia, for example, where red blood cells become misshapen and fail to function properly, doctors will remove cells called hematopoietic stem cells, which will eventually turn into red blood cells and other blood cells.CRISPR breaks ground as a one-shot treatment for a rare disease|Claire Maldarelli|July 28, 2021|Popular-Science
Misfolded proteins can be devastating, causing health problems from sickle cell anemia to cancer and Alzheimer’s disease.Protein Folding AI Is Making a ‘Once in a Generation’ Advance in Biology|Shelly Fan|July 20, 2021|Singularity Hub
Early CRISPR trials have focused on hereditary blindness and diseases of the blood, including cancer, sickle cell anemia, and beta thalassemia.Breakthrough CRISPR Gene Therapy Could Be a ‘One and Done’ Injection|Jason Dorrier|July 1, 2021|Singularity Hub
Inherited blood disorders such as sickle-cell anemia can also lead to anemia.When You Don't Know Where to Turn|Steven J. Bartlett
Scientific definitions for sickle cell anemia
A Closer Look
Sickle cell anemia is a genetic mutation that can be either detrimental or beneficial depending on the number of copies of the mutated gene a person inherits. While it is harmful if a person inherits two copies of the mutated gene (one from each parent), a person could actually benefit if only one copy of the gene is inherited. The defective gene causes red blood cells to be distorted into a sickle shape, which makes it hard for them to pass through the tiny blood vessels where they give oxygen to body tissues. Inheriting two copies of the mutated gene results in a lifelong disease that causes anemia, pain, and other complications. With just one copy of the gene, though, only mild sickling occurs, and the disease does not manifest itself. This mild sickling, however, is also harmful to the parasites that cause malaria and can protect a person from that disease. In a region like tropical Africa where malaria is common, people who have the mutation in one gene are more likely to ward off a malaria infection and to live long enough to have children, who then inherit the gene. And because a person is less likely to inherit two copies of the gene instead of just one, the benefits of the gene outweigh its risks for most people in these regions. About one in 500 African-American newborns and one out of every 1,000 to 1,400 Hispanic babies are diagnosed with sickle cell anemia each year in the United States. Almost ten percent of African Americans carry the sickle cell gene. There is no cure for the disease, but treatment can reduce pain and prolong life.
Cultural definitions for sickle cell anemia
A hereditary form of anemia in which the red blood cells become sickle-shaped (shaped like a crescent) and less able to carry oxygen.