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Synonyms

systemic

American  
[si-stem-ik] / sɪˈstɛm ɪk /

adjective

  1. of or relating to a system, especially when affecting the entirety of a thing.

    systemic flaws in the design and construction of the vehicles.

  2. relating to or noting a policy, practice, or set of beliefs that has been established as normative or customary throughout a political, social, or economic system: systemic racism.

    systemic inequality;

    systemic racism.

  3. Physiology, Pathology.

    1. relating to or affecting the body as a whole.

    2. relating to or affecting a particular body system.

  4. (of a pesticide) absorbed and circulated by a plant or other organism so as to be lethal to pests that feed on it.


systemic British  
/ -ˈstiː-, sɪˈstɛmɪk /

adjective

  1. another word for systematic systematic

  2. physiol (of a poison, disease, etc) affecting the entire body

  3. (of a pesticide, fungicide, etc) spreading through all the parts of a plant and making it toxic to pests or parasites without destroying it

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

noun

  1. a systemic pesticide, fungicide, etc

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • nonsystemic adjective
  • systemically adverb

Etymology

Origin of systemic

First recorded in 1795–1805; system + -ic

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"Seeing both central nervous system changes in brain scans and systemic changes in blood chemistry underscores that these mind-body practices are acting on a whole-body scale."

From Science Daily • Apr. 7, 2026

"We need to recognise this for what it is. A systemic issue. A growing issue. And one that demands a co-ordinated response across government, policing and industry," he added.

From BBC • Apr. 3, 2026

Sister Amy Duggar King said she wasn’t surprised by the allegations and arrest, telling People in an interview published Wednesday that there was a “deeper systemic issue” at play.

From Los Angeles Times • Apr. 1, 2026

That period was defined by a broad-based breakdown in mortgage and credit markets, ultimately exposing systemic weaknesses across the financial system.

From MarketWatch • Mar. 30, 2026

As yet no one seems to have proposed a human systemic that would make us lethal to a mosquito.

From "Silent Spring" by Rachel Carson