trinucleotide
Americannoun
Etymology
Origin of trinucleotide
First recorded in 1915–20; tri- + nucleotide
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
For example, large expansions of repeats of the trinucleotide CAG in the coding sequence of the gene ATXN2 cause spinocerebellar ataxia type 2, in which motor weakness is sometimes an early presentation.
From Nature
The findings explain how the trinucleotide repeat expansion causes RNA-directed gene silencing during development in fragile X syndrome.
From Science Magazine
This trinucleotide motif overlaps the canonical splice acceptor site, possibly accounting for the excess of splice site mutations observed in these tumors.
From Science Magazine
Additionally, separation of mate-pair reads by haplotype may also help to detect expanded trinucleotide repeats in diseases such as Huntington’s disease, even though LFR does not provide direct length measure of these or similar repeats.
From Nature
Often, later generations suffer worse than earlier ones because of a genetic mechanism known as trinucleotide repeat expansion.
From Time Magazine Archive
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
