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Synonyms

mainline

American  
[meyn-lahyn, -lahyn] / ˈmeɪnˌlaɪn, -ˈlaɪn /

verb (used without object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject a narcotic, especially heroin, directly into a vein.

  2. to use or enjoy something without restriction.

    to mainline on TV movies.


verb (used with object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject (a narcotic, especially heroin) directly into a vein.

  2. to use, enjoy, or imbibe (something) without restriction.

    mainlining coffee all day long.

adjective

  1. having a principal, established, or widely accepted position; major; mainstream.

    the membership of mainline churches.

Other Word Forms

Etymology

Origin of mainline

1935–40, v., adj. use of main line

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

“We’ve made it kind of core to who Allegiant is to seek out opportunities that aren’t typically served by mainline carriers,” said Drew Wells, the airline’s chief commercial officer.

From The Wall Street Journal • May 17, 2026

The genius of hit songs, beyond technical artistry—and the vagaries of timing—is the ability to mainline emotion.

From The Wall Street Journal • Mar. 5, 2026

The train operator LNER, which runs the east coast mainline, has extended its advice to passengers not to travel between Edinburgh and Aberdeen as they "cannot guarantee" trains will operate until Friday at the earliest.

From BBC • Jan. 6, 2026

There had been nothing going out on the West Coast mainline and hardly any announcements, she said.

From BBC • Nov. 21, 2025

Like many other evangelicals, some members attend churches that adhere to evangelical doctrine but that remain affiliated with mainline denominations.

From "Class Matters" by The New York Times

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