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Synonyms

pestilence

American  
[pes-tl-uhns] / ˈpɛs tl əns /

noun

  1. a deadly or virulent epidemic disease.

  2. bubonic plague.

  3. something that is considered harmful, destructive, or evil.


pestilence British  
/ ˈpɛstɪləns /

noun

    1. any epidemic outbreak of a deadly and highly infectious disease, such as the plague

    2. such a disease

  1. an evil influence or idea

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of pestilence

First recorded in 1275–1325; Middle English, from Middle French, from Latin pestilentia, from pestilent-, stem of pestilēns “unhealthy, noxious” ( see pestilent) + -ia -y 3 ( def. )

Explanation

Pestilence means a deadly and overwhelming disease that affects an entire community. The Black Plague, a disease that killed over thirty percent of Europe's population, was certainly a pestilence. Pestilence is also one of the Four Horsemen of the Apocalypse in the Book of Revelation (which is part of The Bible). When pestilence rides into town, you want to be somewhere far, far away. Whereas a person gets the flu, a nation experiences a pestilence. A disease that causes widespread crop damage or animal deaths can also be called a pestilence.

Keep Reading on Vocabulary.com

Vocabulary lists containing pestilence

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The plague — aka the Black Death, aka the Great Pestilence — is rarely contracted today, yet it recently infected a South Lake Tahoe resident.

From Los Angeles Times • Aug. 22, 2025

The likelihood of dying from the Great Pestilence was highest amongst those who already faced significant hardship, including exposure to famines that hit England during this time.

From BBC • Nov. 21, 2023

Called “The Conquest of Pestilence in New York City,” it showed how strides in public health eventually quelled the epidemics of the 19th century.

From New York Times • Apr. 7, 2023

Week 1395, a ‘plus-one’ to something known by a number The Five Horsemen of the Apocalypse: War, Famine, Death, Pestilence, and Zeppo.

From Washington Post • Jan. 21, 2021

The Party shall continue unabated, in full festival Mode, for some few weeks thereafter, or until the belittled Pestilence has run its course through the Assembled.

From "The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume I: The Pox Party" by M.T. Anderson